Instructors: Huguenard and Mobley

Course description:  This one credit course will provide topical discussion of recent advances in the neurobiology of disease.  Content will be closely coordinated with the STANFORD BRAIN RESEARCH CENTER Neurobiology of Disease Seminar Series for Winter 2001.

The course will cover a range of topics such as mechanisms of neuro-degenerative syndromes, e.g., Alzheimer's disease, stroke and epilepsy, new experimental treatments, neuronogenesis in the adult brain, and the powerful utility of genetic models in the study of brain disfunction.

An organizational meeting will be held Wednesday, January 17, in H3141.

The first papers to be discussed on January 24th are:

Golden JA, Zitz JC, McFadden K, Cepko CL; Cell migration in the developing chick diencephalon.Development 1997 Sep;124(18):3525-3533

Heffron DS, Golden JA DM-GRASP is Necessary for Nonradial Cell Migration during Chick Diencephalic Development. The Journal of Neuroscience, 2000 March; 20(6):2287-2294.

The papers for January 31st are:

Ferguson JN, Young LJ, Hearn EF, Matzuk MM, Insel TR, Winslow JT. Social amnesia in mice lacking the oxytocin gene Nat Genet. 2000 Jul;25(3):284-8.

Insel, TR, Young, LJ The neurobiology of attachment Nature Reviews, Neuroscience, February, 2001

The papers for February 15th are:

Brazelton TR, Rossi FM, Keshet GI, Blau HM From marrow to brain: expression of neuronal phenotypes in adult mice Science 2000 Dec 1;290(5497):1775-9

Uchida N, Buck DW, He D, Reitsma MJ, Masek M, Phan TV, Tsukamoto AS, Gage FH, Weissman IL. Direct isolation of human central nervous system stem cells Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14720-5.

Yandava BD, Billinghurst LL, Snyder EY. "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci U S A. 1999 Jun 8;96(12):7029-34.

The papers for February 22nd are:

Jennifer A. Johnston, Muffie J. Dalton, Mark E. Gurney, and Ron R. Kopito Formation of high molecular weight complexes of mutant Cu,Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12571-6.

Bruijn LI, Houseweart MK, Kato S, Anderson KL, Anderson SD, Ohama E, Reaume AG, Scott RW,Cleveland DW. Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1.  Science. 1998 Sep 18;281(5384):1851-4.

Kopito RR, Ron D. Conformational disease. Nat Cell Biol. 2000 Nov;2(11):E207.

The papers for Feb 28th are:

He XP, Patel M, Whitney KD, Janumpalli S, Tenner A, McNamara JO Glutamate receptor GluR3 antibodies and death of cortical cells Neuron. 1998 Jan;20(1):153-63

Whitney KD, McNamara JO GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins J Neurosci. 2000 Oct 1;20(19):7307-16.

The papers March 7th are:

Sabina Sperandio, Ian de Belle, and Dale E. Bredesen An alternative, nonapoptotic form of programmed cell death PNAS 97: 14376-14381 602, March, 1998,

D C Lu, S Rabizadeh, S Chandra, R F Shayya, L M Ellerby, X Ye, G S Salvesen, E H Koo & D E Bredesen A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor   Nature Medecine 6:397-404, 2000.

The papers for March 14th are:

Chien-Liang Glenn Lin, Lynn A. Bristol, Lin Jin, Margaret Dykes-Hoberg, Thomas Crawford, Lora Clawson, and Jeffrey D. Rothstein Aberrant RNA Processing in a Neurodegenerative Disease: the Cause for Absent EAAT2, a Glutamate Transporter, in Amyotrophic Lateral Sclerosis Neuron, 20:589-602, 1998

Mandy Jackson, Wei Song, Mu-Ya Liu, Lin Jin, Margaret Dykes-Hoberg, Chien-liang G. Lin, William J. Bowers, Howard J. Federoff, Paul C. Sternweis, R Jeffrey D. Rothstein Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins In Press, Nature

January 25, 2001
Jeffrey Golden, M.D.
University of Pennsylvania School of Medicine
"Neuronal Cell Migration in the Developing Nervous System"
Faculty Host: Ray Sobel (Department of Pathology)

February 1, 2001
Thomas Insel, M.D.
Emory University
"The Neurobiology of Attachment: A Naturalist's Approach to Autism"
Faculty Host: Ben Barres (Department of Neurobiology)

February 15, 2001
Ronald Kopito, Ph.D.
Stanford University
"Protein Aggregation and the Ubiquitin-Proteasome Pathway in the Pathogenesis of Neurodegenerative Disease"
Faculty Host: Linda Cork (Department of Comparative Medicine)

March 1, 2001
James McNamara, M.D.
Duke University
"Autoimmunity and Rasmussen's Encephalitis"
Faculty Host: Rob Malenka (Department of Psychiatry and Behavioral Sciences)

March 8, 2001
Dale Bredesen, M.D.
Buck Institute for Age Research
"Neurodegeneration: The Emerging Paradox"
Faculty Host: Pak Chan (Department of Neurosurgery)

March 15, 2001
Jeffrey Rothstein, M.D., Ph.D.
John Hopkins University
"ALS: Emerging Pathogenesis and Therapies"
Faculty Host: Rona Giffard (Department of Anesthesia)